Determination of Oxycodone Hydrochloride in Oral Solutions by High-Performance Thin-Layer Chromatography/Densitometry

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Determination of oxycodone hydrochloride in oral solutions by high-performance thin-layer chromatography/densitometry.

A thin-layer chromatography/densitometry method was developed and validated for the determination of oxycodone hydrochloride in oral solutions by using silica gel plates. A horizontal technique was used for development of the plates. The optimum composition for the mobile phase, which provided a suitable Rf value of 0.6 for oxycodone, was propanol-acetic acid-water-25% ammonia-methanol (20 + 1 ...

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Simultaneous Estimation of Nebivolol Hydrochloride and S- Amlodipine Besylate by High Performance Thin Layer Chromatography

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A simple and accurate thin-layer chromatographic (TLC) method for quantitative determination of amantadine hydrochloride (AMD) was developed and validated. The method employed TLC aluminum plates pre-coated with silica gel 60F-254 as a stationary phase. The solvent system used for development consisted of n-hexane-methanol-diethylamine (80: 40: 5, v/v/v). The separated spots were visualized as ...

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ژورنال

عنوان ژورنال: Journal of AOAC INTERNATIONAL

سال: 2000

ISSN: 1060-3271,1944-7922

DOI: 10.1093/jaoac/83.6.1497